纪念上海大学建校百年专刊

生物芯片技术与力学

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  • 上海大学 力学与工程科学学院,上海市应用数学和力学研究所,上海 200444 

收稿日期: 2021-12-29

  网络出版日期: 2022-10-21

基金资助

国家自然科学基金项目(12172204、11772182、11272193、10872121)和大学生创新创业训练计划(202010280S210)

Biochip technology and mechanics

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  • Shanghai Institute of Applied Mathematics and Mechanics, School of Mechanics and Engineering Science, Shanghai University, Shanghai 200444, China

Received date: 2021-12-29

  Online published: 2022-10-21

摘要

生物芯片是在固相基底上集成了大量生物分子的微型化、集成化的检测和处理平台,在与生物相关的许多领域均有重大应用。文章主要介绍了生物芯片的发展历史、技术支撑、主要操作步骤和存在的困难,着重分析了生物芯片技术存在的若干关键力学问题,并对未来发展方向进行了初步展望。

本文引用格式

王首智, 张能辉, 任九生 . 生物芯片技术与力学[J]. 自然杂志, 2022 , 44(5) : 382 -388 . DOI: 10.3969/j.issn.0253-9608.2022.04.009

Abstract

Biochip is a miniaturized integrated detection and manipulation platform that integrates a large number of biomolecules on solid substrate, which plays an important role in many fields related to biology. This paper presents a brief review on history, technical supports, manipulation steps and existing difficulties for biochips. Several key mechanical problems in biochip technology are emphatically analyzed with a preliminary prospect of this field.
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