中文

Chinese Journal of Nature ›› 2018, Vol. 40 ›› Issue (6): 435-444.doi: 10.3969/j.issn.0253-9608.2018.06.007

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Focusing on Nav1.7 channel: moving towards pain precision medicine

LIU Yamei①, LIU Yushuang②, ZHANG Jingliang②, WANG Jing①, LI Min①, CHEN Fuxue①,YANG Yang②③   

  1. ①School of Life Science, Shanghai University, Shanghai 200444, China; ②Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University College of Pharmacy, West Lafayette, IN 47907, USA; ③Department of Neurology and Center for Neuroscience and Regeneration Research, School of Medicine, Yale University, New Haven, CT06510, USA
  • Received:2018-12-21 Online:2018-12-25 Published:2018-12-21

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Abstract:

Chronic pain is a global unmet medical need. Most available treatments are only partially effective or have side effects that limit their utilities. Rapid progress has been made to elucidate the contributions of specific genes to the chronic pain, suggesting possibility to advance pain pharmacotherapy. Focusing on voltage-gated sodium channel Nav1.7 as an example, this article reviews recent progress in painpharmacogenomics, new development of disease models using patient-specific induced pluripotent stem cells (iPSCs) derived sensory neurons, as well as advances in structural modeling and electrophysiology recording.These new approaches will hopefully transform the treatment of pain from trial-and-error toward precision pharmacotherapy.