自然杂志 ›› 2007, Vol. 29 ›› Issue (5): 249-254.

• 特约专稿 •    下一篇

转动分子马达：ATP合成酶

舒咬根①;欧阳钟灿②   

  1. 中国科学院理论物理研究所，北京 100080
  • 收稿日期:2007-09-12 修回日期:2007-09-12 出版日期:2007-10-25 发布日期:2007-10-25

Rotary molecular motor: ATP synthase

SHU Yao-gen①;OU-YANG Zhong-can②   

  1. Institute of Theoretical Physics, The Chinese Academy of Sciences, Beijing 100080
  • Received:2007-09-12 Revised:2007-09-12 Online:2007-10-25 Published:2007-10-25

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摘要： 生物分子马达处在生命与纳米两学科的交叉点上，注定会成为本世纪基础研究的主角之一。ATP合成酶是最精妙的生物分子马达之一，有关它的研究尽管经历了60多年，但突破性进展出现在最近十年，部分原因是单分子技术的发展，更要归功于物理学家、生化学家及计算学家等的联合交叉研究。本文回顾了ATP合成酶研究的历程，展示了主要成果，也提出了面临的问题。

关键词: 分子马达, ATP合成酶, 结合变换机制, 自动性, 力学化学耦合

Abstract: Biological molecular motors play a main role in fundamental science in 21st century as a bridge between life science and nanotechnology. ATP synthase is one of the most sophisticated biological molecular motors. Though the investigation of ATP synthase has been carried out for over 60 years, breakthrough has not been made until the recent 10 years, thanks to the interdisciplinary studies of physicists, biochemists and mathematicians, and the development of single molecule technology. This review has presented the major achievements in this field so far and current issues as well.

Key words: molecular motor, ATP synthase, binding change mechanism, motility, mechanochemical coupling

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