自然杂志 ›› 2013, Vol. 35 ›› Issue (6): 436-441.

• 专题综述 • 上一篇    下一篇

秀丽隐杆线虫：一把开启长寿秘密的钥匙

杨平① 费俭②   

  1. ①博士，上海南方模式生物研究中心，上海 201210；②研究员，上海南方模式生物研究中心，上海 201210；同济大学生命科学与技术学院，上海200092
  • 收稿日期:2013-10-09 修回日期:2013-11-09 出版日期:2013-12-25 发布日期:2013-12-25

Caenorhabditis elegans：the key to the secret of longevity

YANG Ping①, FEI Jian②   

  1. ①Ph. D., Shanghai Research Center for Model Organisms, Shanghai 201210, China; ②Professor, Shanghai Research Center for Model Organisms, Shanghai 201210, China; School of Life Sciences and Technology, Tongji University, Shanghai 200092, China
  • Received:2013-10-09 Revised:2013-11-09 Online:2013-12-25 Published:2013-12-25

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摘要： 许多模式生物都被用来开展寿命相关的研究，其中秀丽隐杆线虫因其具有研究周期短、突变体多、在信号通路方面和人类具有高度相似性等优势而广受青睐。在过去的30 多年里，科学家们对线虫的研究使得我们对调控衰老和长寿的分子机制有了飞跃式的进步。

关键词: 模式生物, 秀丽隐杆线虫, 衰老, 长寿

Abstract: Many model organisms were used to study mechanisms of aging and longevity, of which Caenorhabditis elegans is the most widely used one owing to its advantages of short life span, plentiful mutant resource and high conservation in signal pathways with humans. In the past 30 years, scientists have learned a lot from C. elegans research and provided us important informations to understand genetic regulation of longevity and aging.

Key words: model organism, Caenorhabditis elegans, aging, longevity

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