自然杂志 ›› 2026, Vol. 48 ›› Issue (2): 88-98.doi: 10.3969/j.issn.0253-9608.2026.02.002

• 特约专稿 • 上一篇    下一篇

人工智能在非硅基生物存储中的应用与展望

赵紫微,俞洋,宋海涛,李江   

  1. ①上海交通大学 上海人工智能研究院,上海 200240;②上海科技管理干部学院,上海 201800;③上海大学 材料生物学研究所,上海 200444
  • 收稿日期:2025-11-11 出版日期:2026-04-25 发布日期:2026-04-16

Applications and perspective of artificial intelligence in non-silicon-based biological data storage

ZHAO Ziwei, YU Yang, SONG Haitao, LI Jiang   

  1. ① Shanghai Artificial Intelligence Research Institute, Shanghai Jiao Tong University, Shanghai 200240, China; ② Shanghai Institute of Science & Technology Management, Shanghai 201800, China; ③ Institute of Materiobiology, Shanghai University, Shanghai 200444, China
  • Received:2025-11-11 Online:2026-04-25 Published:2026-04-16

摘要: 全球数据正经历爆炸式增长,以硅基介质为代表的传统存储方案在物理极限与可持续性等方面面临严峻挑战。在此背景下,非硅基的生物存储技术逐渐崭露头角,其中以DNA为代表的数据存储路径发展最为迅速,被视为极具潜力的下一代存储方案。DNA数据存储技术以人工合成的脱氧核糖核酸(DNA)分子作为信息载体,具备超高存储密度、千年级稳定性和近乎零维护能耗等颠覆性优势。然而,其在走向实际应用的过程中,仍受限于编码效率、错误率与控制成本、数据检索速度等多重瓶颈。近年来,人工智能(AI)技术的迅猛发展,为突破上述瓶颈注入了全新动力。本文简要介绍DNA存储的原理与挑战,综述AI在DNA存储中的关键应用,重点探讨其在编码优化、错误纠正与高效检索等方面的最新进展,并对当前技术局限与未来发展方向作出展望。

关键词: DNA数据存储, 生物存储, 人工智能, 深度学习, 神经网络

Abstract: Global data is undergoing explosive growth, and traditional storage solutions, represented by silicon-based media, are facing significant challenges in terms of physical limits and sustainability. Hence, non-silicon-based biological storage technologies are gradually emerging, with DNA-based data storage pathways developing most rapidly and regarded as a highly promising nextgeneration storage solution. DNA data storage technology utilizes artificially synthesized deoxyribonucleic acid (DNA) molecules as information carriers, offering revolutionary advantages such as ultra-high storage density, millennial-scale stability, and near-zero maintenance energy consumption. However, its path to practical application remains constrained by multiple bottlenecks, including coding efficiency, error rates and control costs, and data retrieval speed. In recent years, the rapid advancement of artificial intelligence (AI) technology has injected new momentum into overcoming these challenges. This paper briefly introduces the principles and challenges of DNA storage, reviews key applications of AI in DNA storage, with a focus on its latest progress in encoding optimization, error correction, and efficient retrieval, and discusses current technological limitations as well as future development directions.