自然杂志 ›› 2013, Vol. 35 ›› Issue (6): 442-450.

• 专题综述 • 上一篇    下一篇

新药研发: 小斑马鱼, 大机遇

吴转斌① 费俭②   

  1. ①硕士研究生，上海南方模式生物研究中心，上海201210 ②研究员，上海南方模式生物研究中心，上海 201210；
    同济大学生命科学与技术学院，上海200092
  • 收稿日期:2013-10-09 修回日期:2013-11-09 出版日期:2013-12-25 发布日期:2013-12-25

New drug research and development: small fish, big chance

WU Zhuan-bin①, FEI Jian②   

  1. ①Master Candidate, Shanghai Research Center for Model Organisms, Shanghai 201210, China; ②Professor, Shanghai Research
    Center for Model Organisms, Shanghai 201210, China; School of Life Sciences and Technology, Tongji University, Shanghai 200092,
    China
  • Received:2013-10-09 Revised:2013-11-09 Online:2013-12-25 Published:2013-12-25

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688

被引次数

3

摘要： 斑马鱼体积小、发育迅速、胚胎透明、产卵量高, 在信号转导通路、形态学以及生理学方面和哺乳类动物极
其相似, 这些独特优势使得斑马鱼成为人类疾病研究和活体高通量药物筛选的最佳模式生物体之一。近年来, 科学
家们不断地发展出新的斑马鱼疾病模型和新的筛选技术, 利用斑马鱼已经鉴别出多个活性化合物, 并成功通过审批
进入人体临床试验。文章概括介绍了近年来有关斑马鱼的研究在人类疾病模型和药物开发方面所取得的进展, 希望
能够帮助人们了解斑马鱼在新药研发中的应用。

关键词: 斑马鱼, 疾病模型, 药物

Abstract: Taking advantages of small size, rapid and external development, transparent embryo, fecundity, and numerous signal
transduction pathways, morphological and physiological similarities to mammals, zebrafish has emerged as a powerful in vivo
platform for modeling human diseases and large-scale phenotype-based drug screens. Recently, new zebrafish disease models and
screening technologies have been developed. A number of active compounds were identified using zebrafish models that were also
approved in clinical trials. This review surveys the achievements and potential of zebrafish for modeling human diseases and drug
research and development.

Key words:  zebrafish, disease model, drug

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